{"id":1128,"date":"2022-04-28T18:24:35","date_gmt":"2022-04-28T16:24:35","guid":{"rendered":"https:\/\/inserm1193.universite-paris-saclay.fr\/?page_id=1128"},"modified":"2022-09-23T10:43:09","modified_gmt":"2022-09-23T08:43:09","slug":"equipe-4-thierry-tordjmann","status":"publish","type":"page","link":"https:\/\/inserm1193.universite-paris-saclay.fr\/en\/equipes-de-recherche\/equipe-4-thierry-tordjmann\/","title":{"rendered":"Team 4 - Thierry Tordjmann"},"content":{"rendered":"<div class=\"wp-container-1 wp-block-group\">\n<h2 class=\"has-text-align-center has-text-color\" style=\"color:#63003c\"><br><strong>Team 4 - Thierry Tordjmann<\/strong><\/h2>\n\n\n\n<h4 class=\"has-text-align-center has-text-color\" style=\"color:#63003c\"><strong>Biliary homeostasis and liver repair<\/strong><\/h4>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-primary-color has-css-opacity has-primary-background-color has-background alignwide is-style-wide\"\/>\n<\/div>\n\n\n\n<div class=\"wp-container-5 wp-block-group alignwide\">\n<h3 class=\"alignwide has-text-align-center has-background-color has-text-color has-background\" style=\"background-color:#63003c\"><strong>Research activities<\/strong><\/h3>\n\n\n\n<div class=\"wp-container-2 wp-block-group\">\n<h4 class=\"has-text-color\" style=\"color:#63003c\"><strong>1. Biliary homeostasis and liver repair<\/strong><\/h4>\n\n\n\n<h4 class=\"has-text-color\" style=\"color:#63003c\"><strong><em>Supervision: Dr Thierry Tordjmann<\/em><\/strong><\/h4>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-vertically-aligned-center is-style-default\" style=\"grid-template-columns:43% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" width=\"1024\" height=\"746\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/TGR5-mediated-hepatoprotection-1024x746.jpg\" alt=\"\" class=\"wp-image-1460 size-large\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/TGR5-mediated-hepatoprotection-1024x746.jpg 1024w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/TGR5-mediated-hepatoprotection-300x219.jpg 300w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/TGR5-mediated-hepatoprotection-768x560.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/TGR5-mediated-hepatoprotection-1536x1120.jpg 1536w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/TGR5-mediated-hepatoprotection-2048x1493.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-foreground-color has-text-color translation-block\">Even though liver regeneration capacity is\nhuge, tissue repair during chronic injury (biliary or non-biliary etiologies) can lead to hepatic fibrosis. Importantly, after injury and during liver repair, liver functions have to be maintained to fulfill the peripheral demand. This is particularly critical for bile secretion, which has to be finely tuned in order to preserve liver parenchyma from BA-induced injury. However, mechanisms allowing the liver to maintain biliary homeostasis during repair after injury are not completely understood. Our studies are focused on mutual relationships between biliary homeostasis and liver repair. Particular attention is paid to BA and their receptors (TGR5) as potential targets at crucial regulatory crossroads. To this end, we handle in vivo murine models of experimental BA overload, in vitro studies of hepatocytes and cholangiocytes, as well as human patients liver samples (cells and tissues) analysis.<\/p>\n\n\n\n<p class=\" translation-block\"><em>Figure: Schematic representation of the different TGR5-mediated mechanisms of hepato-protection. The integrity of the blood-biliary barrier (BBB), which separates blood from bile, is essential in both physiological and pathological conditions. TGR5 stimulation promotes: - cholangiocyte proliferation and - barrier function by reinforcing cholangiocyte tight junctions. TGR5 regulates chloride and bicarbonate transport in bile, reducing BA protonation and protecting liver parenchyma from BA cytotoxicity. TGR5 have physiological impact on GB functions, possibly including BA reabsorption reported as the cholecysto-hepatic shunt, restricting the amount of toxic secondary BA. TGR5-mediated BA signalling reduces hepatic vascular tone and portal pressure, resulting from sinusoidal vasodilatation (adapted from <a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32145703\/\" target=\"_blank\">Merlen et al., Liver Int 2020;40(5):1005-1015<\/a>).<\/em><\/p>\n\n\n\n<p><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-container-3 wp-block-group\">\n<h4 class=\"has-text-color\" style=\"color:#63003c\"><strong>2. <strong>Pathophysiology and treatment of genetic cholestasis<\/strong><\/strong><\/h4>\n\n\n\n<h4 class=\"has-text-color\" style=\"color:#63003c\"><strong><em>Supervision: Pr Emmanuel Jacquemin<\/em><\/strong><\/h4>\n\n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile is-vertically-aligned-center is-style-default\" style=\"grid-template-columns:auto 43%\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" width=\"1024\" height=\"750\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Genetic-variations-of-ABC-transporters-1024x750.jpg\" alt=\"\" class=\"wp-image-1475 size-large\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Genetic-variations-of-ABC-transporters-1024x750.jpg 1024w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Genetic-variations-of-ABC-transporters-300x220.jpg 300w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Genetic-variations-of-ABC-transporters-768x562.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Genetic-variations-of-ABC-transporters-1536x1125.jpg 1536w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Genetic-variations-of-ABC-transporters.jpg 1890w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-foreground-color has-text-color translation-block\">Chronic cholestatic liver diseases can have genetic\norigins, due to molecular defects of ABC transporters localized at the canalicular membrane of hepatocytes.\nIndeed, genetic variations of ABCB11\/BSEP (bile acid transporter) and ABCB4\/MDR3 (phospholipid\ntransporter) are implicated in rare and severe forms of genetic cholestasis named progressive familial\nintrahepatic cholestasis types 2 and 3, respectively. These diseases are characterized by chronic\ncholestasis, icterus and moderate to severe pruritus, and they mostly evolve to liver failure, thus requiring\nliver transplantation. The aim of our studies is to identify new molecules able to correct the molecular\ndefects of the mutated canalicular ABC transporters (expression, traffic or function), in the frame of genetic\ncholestasis. As a first line of research, we use cell models expressing the defective transporters in order to\nidentify molecules able to rescue the defective canalicular ABC transporters. Then, we will validate the best\nmolecules at a preclinical stage in humanized mouse models mimicking the human pathologies (KO mice\nexpressing the mutated human canalicular transporters by viral infection) before considering their\nvalorisation and transfer to the clinic.<\/p>\n\n\n\n<p class=\" translation-block\"><em><em>Figure: Schematic representation of the classes of genetic variants of canalicular ABC transporters. The classes were determined on the basis of the deficit identified in cell models. Class I corresponds to nonsense variants (premature stop codons) leading to extremely reduced or even no protein expression. Class II, III and IV variants are mainly missense variants (replacement of one amino acid by another) whose deficiency is linked to defects in intracellular trafficking, activity or stability, respectively. Class V variants have no apparent defect, identifiable by the experimental approaches used and could correspond to non-deleterious polymorphisms (adapted from <a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28245962\/\" target=\"_blank\">Vauthier et al., Biochem Pharmacol 2017;136:1-11<\/a>).<\/em><\/em><\/p>\n\n\n\n<p><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-container-4 wp-block-group\">\n<h4 class=\"has-text-color\" style=\"color:#63003c\"><strong>3. <strong>Cellular mechanisms of ciliopathies and biliary organogenesis<\/strong><\/strong><\/h4>\n\n\n\n<h4 class=\"has-text-color\" style=\"color:#63003c\"><strong><em>Supervision: Dr Pascale Dupuis-Williams<\/em><\/strong><\/h4>\n\n\n\n<p>The construction during embryogenesis\nand the maintenance of a functional biliary system rely on the role of the primary cilium, as exemplified by the biliary diseases associated to ciliopathies. Although much work has helped to elucidate the role of the\ncholangiocyte primary cilium in signaling and in regulating bile homeostasis, its function in biliary organogenesis remains to be elucidated. In this context, our group focuses on Ciliopathies and Biliary Organogenesis. Its activities are developed according to two axes: i) a research program intended to\ndecipher the role in cholangiocytes epithelial polarity of ciliary proteins involved in bile dysgenesis and ii) a bioengineering activity aiming in the construction of biliary tubes to provide models of in vitro biliary development and for regenerative medicine. <em>in vitro<\/em> et des outils pour la m\u00e9decine r\u00e9g\u00e9n\u00e9rative.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-container-42 wp-block-group alignfull\">\n<h3 class=\"alignwide has-text-align-center has-background-color has-text-color has-background\" style=\"background-color:#63003c\"><strong>Team members<\/strong><\/h3>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\">RESEARCHERS AND LECTURERS<\/h5>\n\n\n\n<div class=\"wp-container-11 is-layout-flex wp-block-columns alignfull\">\n<div class=\"wp-container-6 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized is-style-default\" style=\"border-radius:0px\"><img loading=\"lazy\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/04\/No-picture-homme.webp\" alt=\"\" class=\"wp-image-915\" width=\"180\" height=\"180\"\/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Olivier DELLIS<\/strong><br>Associate professor<br>Universit\u00e9 Paris-Saclay<br><a href=\"Tel:01-69-15-49-59\">01-69-15-49-59<\/a><br><a href=\"mailto:olivier.dellis@universite-paris-saclay.fr\">olivier.dellis@universite-paris-saclay.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-7 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/09\/Pascale-Dupuis-Williams-878x1024.jpg\" alt=\"\" class=\"wp-image-1936\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/09\/Pascale-Dupuis-Williams-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/09\/Pascale-Dupuis-Williams-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/09\/Pascale-Dupuis-Williams-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/09\/Pascale-Dupuis-Williams-10x12.jpg 10w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/09\/Pascale-Dupuis-Williams.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Pascale DUPUIS-WILLIAMS<\/strong><br>Associate professor<br>ESPCI Paris<br><a href=\"Tel:01-69-15-68-66\">01-69-15-68-66<\/a><br><a href=\"mailto:pascale.dupuis-williams@universite-paris-saclay.fr\">pascale.dupuis-williams@universite-paris-saclay.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-8 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thomas-Falguieres-878x1024.jpg\" alt=\"\" class=\"wp-image-1378\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thomas-Falguieres-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thomas-Falguieres-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thomas-Falguieres-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thomas-Falguieres.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Thomas FALGUIERES<\/strong><br>Research Associate<br>Inserm<br><a href=\"Tel:01-69-15-62-94\">01-69-15-62-94<\/a><br><a href=\"mailto:thomas.falguieres@inserm.fr\">thomas.falguieres@inserm.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-9 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Gregory-Merlen-1-878x1024.jpg\" alt=\"\" class=\"wp-image-1389\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Gregory-Merlen-1-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Gregory-Merlen-1-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Gregory-Merlen-1-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Gregory-Merlen-1.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Gr\u00e9gory MERLEN<\/strong><br>Research Associate<br>Inserm<br><a href=\"Tel:01-69-15-68-59\">01-69-15-68-59<\/a><br><a href=\"mailto:gregory.merlen@inserm.fr\">gregory.merlen@inserm.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-10 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Thierry-Tordjmann-2-878x1024.jpg\" alt=\"\" class=\"wp-image-1786\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Thierry-Tordjmann-2-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Thierry-Tordjmann-2-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Thierry-Tordjmann-2-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Thierry-Tordjmann-2.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Thierry TORDJMANN<\/strong><br>Research Director<br>Inserm<br><a href=\"Tel:01-69-15-68-63\">01-69-15-68-63<\/a><br><a href=\"mailto:thierry.tordjmann@universite-paris-saclay.fr\">thierry.tordjmann@universite-paris-saclay.fr<\/a><\/h4>\n<\/div>\n<\/div>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\">PHYSICIANS<\/h5>\n\n\n\n<div class=\"wp-container-16 is-layout-flex wp-block-columns alignfull\">\n<div class=\"wp-container-12 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Oanez-Ackermann-878x1024.jpg\" alt=\"\" class=\"wp-image-1376\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Oanez-Ackermann-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Oanez-Ackermann-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Oanez-Ackermann-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Oanez-Ackermann.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Oanez ACKERMANN<\/strong><br>Paediatric hepatologist<br>AP-HP<br><a href=\"Tel:01-45-21-31-67\">01-45-21-31-67<\/a><br><a href=\"mailto:oanez.ackermann@aphp.fr\">oanez.ackermann@aphp.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-13 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized is-style-default\" style=\"border-radius:0px\"><img loading=\"lazy\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/04\/No-Picture-femme.jpg\" alt=\"\" class=\"wp-image-916\" width=\"180\" height=\"180\"\/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Marion ALMES<\/strong><br>Assistant professor<br>AP-HP \/ Universit\u00e9-Paris-Saclay<br><a href=\"Tel:01-45-21-31-67\">01-45-21-31-67<\/a><br><a href=\"mailto:marionflorence.almes@aphp.fr\">marionflorence.almes@aphp.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-14 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Gonzales-878x1024.jpg\" alt=\"\" class=\"wp-image-1370\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Gonzales-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Gonzales-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Gonzales-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Gonzales.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Emmanuel GONZALES<\/strong><br>Full professor<br>AP-HP \/ Universit\u00e9-Paris-Saclay<br><a href=\"Tel:01-45-21-31-67\">01-45-21-31-67<\/a><br><a href=\"mailto:emmanuel.gonzales@aphp.fr\">emmanuel.gonzales@aphp.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-15 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized is-style-default\" style=\"border-radius:0px\"><img loading=\"lazy\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/04\/No-Picture-femme.jpg\" alt=\"\" class=\"wp-image-916\" width=\"180\" height=\"180\"\/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Dalila HABES<\/strong><br>Paediatric hepatologist<br>AP-HP<br><a href=\"Tel:01-45-21-31-67\">01-45-21-31-67<\/a><br><a href=\"mailto:dalila.habes@aphp.fr\">dalila.habes@aphp.fr<\/a><\/h4>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-container-21 is-layout-flex wp-block-columns alignfull\">\n<div class=\"wp-container-17 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized is-style-default\" style=\"border-radius:0px\"><img loading=\"lazy\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/04\/No-picture-homme.webp\" alt=\"\" class=\"wp-image-915\" width=\"180\" height=\"180\"\/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Bogdan HERMEZIU<\/strong><br>Paediatric hepatologist<br>AP-HP<br><a href=\"Tel:01-45-21-31-67\">01-45-21-31-67<\/a><br><a href=\"mailto:bogdan.hermeziu@aphp.fr\">bogdan.hermeziu@aphp.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-18 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Jacquemin-878x1024.jpg\" alt=\"\" class=\"wp-image-1371\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Jacquemin-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Jacquemin-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Jacquemin-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Emmanuel-Jacquemin.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Emmanuel JACQUEMIN<\/strong><br>Full professor<br>AP-HP \/ Universit\u00e9-Paris-Saclay<br><a href=\"Tel:01-45-21-31-67\">01-45-21-31-67<\/a><br><a href=\"mailto:emmanuel.jacquemin@aphp.fr\">emmanuel.jacquemin@aphp.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-19 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized is-style-default\" style=\"border-radius:0px\"><img loading=\"lazy\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/04\/No-Picture-femme.jpg\" alt=\"\" class=\"wp-image-916\" width=\"180\" height=\"180\"\/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Anne SPRAUL<\/strong><br>Paediatric hepatologist<br>AP-HP<br><a href=\"Tel:01-45-21-35-22\">01-45-21-35-22<\/a><br><a href=\"mailto:anne.spraul@aphp.fr\">anne.spraul@aphp.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-20 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized is-style-default\" style=\"border-radius:0px\"><img loading=\"lazy\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/04\/No-Picture-femme.jpg\" alt=\"\" class=\"wp-image-916\" width=\"180\" height=\"180\"\/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Alice THEBAUT<\/strong><br>Paediatric hepatologist<br>AP-HP<br><a href=\"Tel:01-45-21-31-67\">01-45-21-31-67<\/a><br><a href=\"mailto:alice.thebaut@aphp.fr\">alice.thebaut@aphp.fr<\/a><\/h4>\n<\/div>\n<\/div>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\">ENGINEERS AND TECHNICIANS<\/h5>\n\n\n\n<div class=\"wp-container-26 is-layout-flex wp-block-columns alignfull\">\n<div class=\"wp-container-22 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Manon-Banet-3-878x1024.jpg\" alt=\"\" class=\"wp-image-1390\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Manon-Banet-3-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Manon-Banet-3-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Manon-Banet-3-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Manon-Banet-3.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Manon BANET<\/strong><br>Study engineer (contract)<br>Inserm (ANR)<br><a href=\"Tel:01-69-15-62-94\">01-69-15-62-94<\/a><br><a href=\"mailto:manon.banet@inserm.fr\">manon.banet@inserm.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-23 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Latifa-Bouzhir-878x1024.jpg\" alt=\"\" class=\"wp-image-1373\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Latifa-Bouzhir-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Latifa-Bouzhir-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Latifa-Bouzhir-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Latifa-Bouzhir.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Latifa BOUZHIR<\/strong><br>Study engineer<br>Inserm<br><a href=\"Tel:01-69-15-68-56\">01-69-15-68-56<\/a><br><a href=\"mailto:latifa.bouzhir@universite-paris-saclay.fr\">latifa.bouzhir@universite-paris-saclay.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-24 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Khadidiatou-Diarra-2-878x1024.jpg\" alt=\"\" class=\"wp-image-1790\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Khadidiatou-Diarra-2-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Khadidiatou-Diarra-2-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Khadidiatou-Diarra-2-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Khadidiatou-Diarra-2.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Khadidiatou DIARRA<\/strong><br>Technical assistant<br>Inserm<br><a href=\"Tel:01-69-15-68-58\">01-69-15-68-58<\/a><br><a href=\"mailto:khadidiatou.diarra@inserm.fr\">khadidiatou.diarra@inserm.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-25 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Isabelle-Doignon-2-878x1024.jpg\" alt=\"\" class=\"wp-image-1787\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Isabelle-Doignon-2-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Isabelle-Doignon-2-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Isabelle-Doignon-2-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/06\/Isabelle-Doignon-2.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Isabelle DOIGNON<\/strong><br>Study engineer<br>Inserm<br><a href=\"Tel:01-69-15-68-64\">01-69-15-68-64<\/a><br><a href=\"mailto:isabelle.doignon@universite-paris-saclay.fr\">isabelle.doignon@universite-paris-saclay.fr<\/a><\/h4>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-container-31 is-layout-flex wp-block-columns alignfull\">\n<div class=\"wp-container-27 wp-block-column\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Olivier-Fayol-878x1024.jpg\" alt=\"\" class=\"wp-image-1377\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Olivier-Fayol-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Olivier-Fayol-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Olivier-Fayol-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Olivier-Fayol.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Olivier FAYOL<\/strong><br>Technician<br>Universit\u00e9 Paris-Saclay<br><a href=\"Tel:01-69-15-63-96\">01-69-15-63-96<\/a><br><a href=\"mailto:olivier.fayol@universite-paris-saclay.fr\">olivier.fayol@universite-paris-saclay.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-28 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Isabelle-Garcin-878x1024.jpg\" alt=\"\" class=\"wp-image-1402\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Isabelle-Garcin-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Isabelle-Garcin-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Isabelle-Garcin-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Isabelle-Garcin.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Isabelle GARCIN<\/strong><br>Study engineer<br>Universit\u00e9 Paris-Saclay<br><a href=\"Tel:01-69-15-76-39\">01-69-15-76-39<\/a><br><a href=\"mailto:isabelle.garcin@universite-paris-saclay.fr\">isabelle.garcin@universite-paris-saclay.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-29 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Martine-Lapalus-878x1024.jpg\" alt=\"\" class=\"wp-image-1403\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Martine-Lapalus-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Martine-Lapalus-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Martine-Lapalus-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Martine-Lapalus.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Martine LAPALUS<\/strong><br>Research engineer<br>Inserm<br><a href=\"Tel:01-69-15-39-25\">01-69-15-39-25<\/a><br><a href=\"mailto:martine.lapalus@universite-paris-saclay.fr\">martine.lapalus@universite-paris-saclay.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-30 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><\/div>\n<\/div>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\">PHD STUDENTS AND POST-DOCS<\/h5>\n\n\n\n<div class=\"wp-container-36 is-layout-flex wp-block-columns alignfull\">\n<div class=\"wp-container-32 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Chloe-Caenen-878x1024.jpg\" alt=\"\" class=\"wp-image-1369\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Chloe-Caenen-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Chloe-Caenen-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Chloe-Caenen-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Chloe-Caenen.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Chlo\u00e9 CAENEN<\/strong><br>PhD student<br>Universit\u00e9 Paris-Saclay<br><a href=\"Tel:01-69-15-58-24\">01-69-15-58-24<\/a><br><a href=\"mailto:chloe.caenen@inserm.fr\">chloe.caenen@inserm.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-33 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Mounia-Lakli-878x1024.jpg\" alt=\"\" class=\"wp-image-1375\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Mounia-Lakli-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Mounia-Lakli-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Mounia-Lakli-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Mounia-Lakli.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Mounia LAKLI<\/strong><br>PhD student<br>Universit\u00e9 Paris-Saclay<br><a href=\"Tel:01-69-15-62-94\">01-69-15-62-94<\/a><br><a href=\"mailto:mounia.lakli@inserm.fr\">mounia.lakli@inserm.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-34 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\" style=\"border-radius:0px\"><img src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thibault-Pebrier-878x1024.jpg\" alt=\"\" class=\"wp-image-1430\" width=\"180\" srcset=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thibault-Pebrier-878x1024.jpg 878w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thibault-Pebrier-257x300.jpg 257w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thibault-Pebrier-768x896.jpg 768w, https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/05\/Thibault-Pebrier.jpg 945w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>Thibault PEBRIER<\/strong><br>PhD student<br>Universit\u00e9 Paris-Saclay<br><a href=\"Tel:01-69-15-63-96\">01-69-15-63-96<\/a><br><a href=\"mailto:thibault.pebrier@universite-paris-saclay.fr\">thibault.pebrier@universite-paris-saclay.fr<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-35 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><\/div>\n<\/div>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\">ALUMNI<\/h5>\n\n\n\n<div class=\"wp-container-41 is-layout-flex wp-block-columns alignfull\">\n<div class=\"wp-container-37 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized is-style-default\" style=\"border-radius:0px\"><img loading=\"lazy\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/04\/No-picture-homme.webp\" alt=\"\" class=\"wp-image-915\" width=\"180\" height=\"180\"\/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>XXX XXXXX<\/strong><br>XXXX<br>XXXXXXXXXX<br><a href=\"Tel:01-XX-XX-XX-XX\">01-XX-XX-XX-XX<\/a><br><a href=\"mailto:xxxx.xxxxx@xxxx.com\">xxxx.xxxxx@xxxx.com<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-38 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized is-style-default\" style=\"border-radius:0px\"><img loading=\"lazy\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/04\/No-picture-homme.webp\" alt=\"\" class=\"wp-image-915\" width=\"180\" height=\"180\"\/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>XXX XXXXX<\/strong><br>XXXX<br>XXXXXXXXXX<br><a href=\"Tel:01-XX-XX-XX-XX\">01-XX-XX-XX-XX<\/a><br><a href=\"mailto:xxxx.xxxxx@xxxx.com\">xxxx.xxxxx@xxxx.com<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-39 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized is-style-default\" style=\"border-radius:0px\"><img loading=\"lazy\" src=\"https:\/\/inserm1193.universite-paris-saclay.fr\/wp-content\/uploads\/2022\/04\/No-picture-homme.webp\" alt=\"\" class=\"wp-image-915\" width=\"180\" height=\"180\"\/><\/figure>\n\n\n\n<h4 class=\"has-text-align-center has-medium-font-size\"><strong>XXX XXXXX<\/strong><br>XXXX<br>XXXXXXXXXX<br><a href=\"Tel:01-XX-XX-XX-XX\">01-XX-XX-XX-XX<\/a><br><a href=\"mailto:xxxx.xxxxx@xxxx.com\">xxxx.xxxxx@xxxx.com<\/a><\/h4>\n<\/div>\n\n\n\n<div class=\"wp-container-40 wp-block-column\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-container-43 wp-block-group alignwide\">\n<h3 class=\"alignwide has-text-align-center has-background-color has-text-color has-background\" style=\"background-color:#63003c\"><strong>Main publications<\/strong><\/h3>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\"><strong>2022<\/strong><\/h5>\n\n\n\n<ul class=\"has-medium-font-size\"><li><strong><a href=\"https:\/\/www.mdpi.com\/1422-0067\/23\/18\/10758\" target=\"_blank\" rel=\"noreferrer noopener\"><em>In Vitro <\/em>Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators.<\/a><\/strong> Mareux E, Lapalus M, Ben Saad A, Zelli R, Lakli M, Riahi Y, Almes M, Banet M, Callebaut I, Decout JL, Falgui\u00e8res T, Jacquemin E, Gonzales E. <strong>Int J Mol Sci. 2022<\/strong> Sept 15;23(18):10758. doi:10.3390\/ijms231810758.<\/li><li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35457067\/\" target=\"_blank\" rel=\"noreferrer noopener\">ABC Transporters in Human Diseases: Future Directions and Therapeutic Perspectives.<\/a><\/strong> Falgui\u00e8res T. <strong>Int J Mol Sci. 2022<\/strong> Apr 12;23(8):4250. doi: 10.3390\/ijms23084250. PMID: 35457067.<\/li><\/ul>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\"><strong>2021<\/strong><\/h5>\n\n\n\n<ul class=\"has-medium-font-size\"><li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961221005640?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Construction of functional biliary epithelial branched networks with predefined geometry using digital light stereolithography.<\/strong><\/a> Mazari-Arrighi E, Ayollo D, Farhat W, Marret A, Gontran E, Dupuis-Williams P, Larghero J, Chatelain F, Fuchs A.  <strong>Biomaterials. 2021 <\/strong>Dec;279:121207. doi: 10.1016\/j.biomaterials.2021.121207. PMID: 34741977.<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34755627\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study.<\/strong><\/a> Gonzales E, Hardikar W, Stormon M, Baker A, Hierro L, Gliwicz D, Lacaille F, Lachaux A, Sturm E, Setchell KDR, Kennedy C, Dorenbaum A, Steinmetz J, Desai NK, Wardle AJ, Garner W, Vig P, Jaecklin T, Sokal EM, Jacquemin E. <strong>Lancet. 2021 <\/strong>Oct 30;398(10311):1581-1592. doi: 10.1016\/S0140-6736(21)01256-3. PMID: 34755627.<\/li><li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34794484\/\" target=\"_blank\" rel=\"noreferrer noopener\">In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy.<\/a><\/strong> Mareux E, Lapalus M, Ben-Saad A, Callebaut I, Falgui\u00e8res T, Gonzales E, Jacquemin E. <strong>Orphanet J Rare Dis. 2021 <\/strong>Nov 18;16(1):484. doi: 10.1186\/s13023-021-02125-4. PMID: 34794484.<\/li><li><strong><a href=\"https:\/\/www.mdpi.com\/2306-5354\/8\/8\/112\" target=\"_blank\" rel=\"noreferrer noopener\">Self-Organogenesis from 2D Micropatterns to 3D Biomimetic Biliary Trees.<\/a><\/strong> Gontran E, Loarca L, El Kassis C, Bouzhir L, Ayollo D, Mazari-Arrighi E, Fuchs A, Dupuis-Williams P. <strong>Bioengineering (Basel). 2021 <\/strong>Aug 5;8(8):112. doi: 10.3390\/bioengineering8080112. PMID: 34436115.<\/li><li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34209301\/\" target=\"_blank\" rel=\"noreferrer noopener\">RAB10 Interacts with ABCB4 and Regulates Its Intracellular Traffic.<\/a><\/strong> Ben Saad A, Vauthier V, Lapalus M, Mareux E, Bennana E, Durand-Schneider AM, Bruneau A, Delaunay JL, Gonzales E, Housset C, A\u00eft-Slimane T, Guillonneau F, Jacquemin E, Falgui\u00e8res T. <strong>Int J Mol Sci. 2021 <\/strong>Jun 30;22(13):7087. doi: 10.3390\/ijms22137087. PMID: 34209301.<\/li><li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33672718\/\" target=\"_blank\" rel=\"noreferrer noopener\">Molecular Regulation of Canalicular ABC Transporters.<\/a><\/strong> Ben Saad A, Bruneau A, Mareux E, Lapalus M, Delaunay JL, Gonzales E, Jacquemin E, A\u00eft-Slimane T, Falgui\u00e8res T. <strong>Int J Mol Sci. 2021 <\/strong>Feb 20;22(4):2113. doi: 10.3390\/ijms22042113. PMID: 33672718.<\/li><li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33650203\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants.<\/a><\/strong> Ben Saad A, Vauthier V, T\u00f3th \u00c1, Janaszkiewicz A, Durand-Schneider AM, Bruneau A, Delaunay JL, Lapalus M, Mareux E, Garcin I, Gonzales E, Housset C, A\u00eft-Slimane T, Jacquemin E, Di Meo F, Falgui\u00e8res T. <strong>Liver Int. 2021 <\/strong>Jun;41(6):1344-1357. doi: 10.1111\/liv.14839. PMID: 33650203.<\/li><li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33492227\/\" target=\"_blank\" rel=\"noreferrer noopener\">[The EGFR ligand amphiregulin protects from cholestatic liver injury].<\/a><\/strong> Sidib\u00e9 N, Jalabert H, Merlen G, Tordjmann T. R\u00f4le h\u00e9pato-protecteur de l\u2019amphir\u00e9guline, un ligand du r\u00e9cepteur de l\u2019EGF, en situation de cholestase <strong>Med Sci (Paris). 2021 <\/strong>Jan;37(1):103-105. French. doi: 10.1051\/medsci\/2020265. PMID: 33492227.<\/li><li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32702170\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pharmacological Premature Termination Codon Readthrough of ABCB11 in Bile Salt Export Pump Deficiency: An In Vitro Study.<\/a><a href=\"https:\/\/linkout.ebsco.zone\/ftf?ref=bf9db4ef-27ba-48c0-8434-013d0f8640ca&amp;id=301728\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/strong> Amzal R, Th\u00e9baut A, Lapalus M, Almes M, Grosse B, Mareux E, Collado-Hilly M, Davit-Spraul A, Bidou L, Namy O, Jacquemin E, Gonzales E. <strong>Hepatology. 2021 <\/strong>Apr;73(4):1449-1463. doi: 10.1002\/hep.31476. PMID: 32702170.<\/li><li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32565202\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ursodeoxycholic acid therapy throughout pregnancy in women affected with chronic cholestasis of childhood: No evidence for teratogenicity.<\/a><a href=\"https:\/\/linkout.ebsco.zone\/ftf?ref=06468ea8-a715-448f-a376-c1d501853e84&amp;id=301728\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/strong> Lykavieris P, Bernard O, Jacquemin E. <strong>Clin Res Hepatol Gastroenterol. 2021 <\/strong>May;45(3):101472. doi: 10.1016\/j.clinre.2020.05.020. PMID: 32565202.<\/li><li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33908862\/\" target=\"_blank\" rel=\"noreferrer noopener\">[Rituximab in the treatment of diffuse large B-cell lymphoma: The CACNA1C subunit of channel Cav1.2 expression linked to certain forms of resistance].<\/a><\/strong> Bouabdallah S, Mariko ML, Besson J, Dellis O. Le rituximab dans le traitement du lymphome diffus \u00e0 grandes cellules B &#8211; L\u2019expression de la sous-unit\u00e9 CACNA1C du canal Cav 1.2 li\u00e9e \u00e0 certaines formes de r\u00e9sistance. <strong>Med Sci (Paris). 2021 <\/strong>Apr;37(4):406-408. French. doi: 10.1051\/medsci\/2021043. PMID: 33908862.<\/li><\/ul>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\"><strong>2020<\/strong><\/h5>\n\n\n\n<ul class=\"has-medium-font-size\"><li><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33604531\/\" target=\"_blank\"><strong>TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload.<\/strong><\/a> Bidault-Jourdainne V, Merlen G, Gl\u00e9nisson M, Doignon I, Garcin I, P\u00e9an N, Boisgard R, Ursic-Bedoya J, Serino M, Ullmer C, Humbert L, Abdelrafee A, Golse N, Vibert E, Duclos-Vall\u00e9e JC, Rainteau D, Tordjmann T. <strong>JHEP Rep. 2020 <\/strong>Nov 11;3(2):100214. doi: 10.1016\/j.jhepr.2020.100214. PMID: 33604531.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33371518\/\" target=\"_blank\">Synthesis and Characterization of Store-Operated Calcium Entry Inhibitors Active in the Submicromolar Range.<\/a><\/strong> Le Guilcher C, Luyten T, Parys JB, Pucheault M, Dellis O. <strong>Int J Mol Sci. 2020<\/strong> Dec 21;21(24):9777. doi: 10.3390\/ijms21249777. PMID: 33371518.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32478726\/\" target=\"_blank\">Generation and Quantitative Characterization of Functional and Polarized Biliary Epithelial Cysts.<\/a><\/strong> Bouzhir L, Gontran E, Loarca L, Collado-Hilly M, Dupuis-Williams P.  <strong>J Vis Exp. 2020 <\/strong>May 16;(159). doi: 10.3791\/61404. PMID: 32478726.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32443059\/\" target=\"_blank\">Glycerol Phenylbutyrate Therapy in Progressive Familial Intrahepatic Cholestasis Type 2.<\/a><\/strong> Almes M, Jobert A, Lapalus M, Mareux E, Gonzales E, Jacquemin E. <strong>J Pediatr Gastroenterol Nutr. 2020 <\/strong>Jun;70(6):e139-e140. doi: 10.1097\/MPG.0000000000002713. PMID: 32443059.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32433800\/\" target=\"_blank\">Functional rescue of an ABCB11 mutant by ivacaftor: A new targeted pharmacotherapy approach in bile salt export pump deficiency.<\/a><\/strong> Mareux E, Lapalus M, Amzal R, Almes M, A\u00eft-Slimane T, Delaunay JL, Adnot P, Collado-Hilly M, Davit-Spraul A, Falgui\u00e8res T, Callebaut I, Gonzales E, Jacquemin E.<strong> Liver Int. 2020 <\/strong>Aug;40(8):1917-1925. doi: 10.1111\/liv.14518. PMID: 32433800.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32145703\/\" target=\"_blank\">Hepatoprotective impact of the bile acid receptor TGR5.<\/a><\/strong> Merlen G, Bidault-Jourdainne V, Kahale N, Glenisson M, Ursic-Bedoya J, Doignon I, Garcin I, Humbert L, Rainteau D, Tordjmann T. <strong>Liver Int. 2020 <\/strong>May;40(5):1005-1015. doi: 10.1111\/liv.14427. PMID: 32145703.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32087350\/\" target=\"_blank\">Genotype correlates with the natural history of severe bile salt export pump deficiency.<\/a><\/strong> van Wessel DBE, Thompson RJ, Gonzales E, Jankowska I, Sokal E, Grammatikopoulos T, Kadaristiana A, Jacquemin E, Spraul A, Lipi\u0144ski P, Czubkowski P, Rock N, Shagrani M, Broering D, Algoufi T, Mazhar N, Nicastro E, Kelly DA, Nebbia G, Arnell H, Bj\u00f6rn Fischler, Hulscher JBF, Serranti D, Arikan C, Polat E, Debray D, Lacaille F, Goncalves C, Hierro L, Mu\u00f1oz Bartolo G, Mozer-Glassberg Y, Azaz A, Brecelj J, Dezs\u0151fi A, Calvo PL, Grabhorn E, Sturm E, van der Woerd WJ, Kamath BM, Wang JS, Li L, Durmaz \u00d6, Onal Z, Bunt TMG, Hansen BE, Verkade HJ; NAtural course and Prognosis of PFIC and Effect of biliary Diversion (NAPPED) consortium. <strong>J Hepatol. 2020 <\/strong>Jul;73(1):84-93. doi: 10.1016\/j.jhep.2020.02.007. PMID: 32087350.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31633655\/\" target=\"_blank\">A Novel CFC1 Mutation in a Family With Heterotaxy and Biliary Atresia Splenic Malformation Syndromes.<\/a><\/strong> Gonzales E, Davit-Spraul A, Jacquemin E. <strong>J Pediatr Gastroenterol Nutr. 2020 <\/strong>Jan;70(1):e24-e25. doi: 10.1097\/MPG.0000000000002531. PMID: 31633655.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30723104\/\" target=\"_blank\">TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function.<\/a><\/strong> Merlen G, Kahale N, Ursic-Bedoya J, Bidault-Jourdainne V, Simerabet H, Doignon I, Tanfin Z, Garcin I, P\u00e9an N, Gautherot J, Davit-Spraul A, Guettier C, Humbert L, Rainteau D, Ebnet K, Ullmer C, Cassio D, Tordjmann T. <strong>Gut. 2020 <\/strong>Jan;69(1):146-157. doi: 10.1136\/gutjnl-2018-316975. PMID: 30723104.<\/li><\/ul>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\"><strong>2019<\/strong><\/h5>\n\n\n\n<ul class=\"has-medium-font-size\"><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31921820\/\" target=\"_blank\">Biophysical Control of Bile Duct Epithelial Morphogenesis in Natural and Synthetic Scaffolds.<\/a><\/strong> Funfak A, Bouzhir L, Gontran E, Minier N, Dupuis-Williams P, Gobaa S. <strong>Front Bioeng Biotechnol. 2019 <\/strong>Dec 13;7:417. doi: 10.3389\/fbioe.2019.00417. PMID: 31921820.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31320998\/\" target=\"_blank\">Improvement of the rituximab-induced cell death by potentiation of the store-operated calcium entry in mantle cell lymphoma cell lines.<\/a><\/strong> Doignon I, Fayol O, Dellis O. <strong>Oncotarget. 2019 <\/strong>Jul 9;10(43):4466-4478. doi: 10.18632\/oncotarget.27063. PMID: 31320998.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31040306\/\" target=\"_blank\">Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.<\/a><\/strong> Vauthier V, Ben Saad A, Elie J, Oumata N, Durand-Schneider AM, Bruneau A, Delaunay JL, Housset C, A\u00eft-Slimane T, Meijer L, Falgui\u00e8res T. <strong>Sci Rep. 2019 <\/strong>Apr 30;9(1):6653. doi: 10.1038\/s41598-019-43111-y. PMID: 31040306.<\/li><\/ul>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\"><strong>2018<\/strong><\/h5>\n\n\n\n<ul class=\"has-medium-font-size\"><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30373615\/\" target=\"_blank\">Cholic acid for primary bile acid synthesis defects: a life-saving therapy allowing a favorable outcome in adulthood.<\/a><\/strong> Gonzales E, Matarazzo L, Franchi-Abella S, Dabadie A, Cohen J, Habes D, Hillaire S, Guettier C, Taburet AM, Myara A, Jacquemin E. <strong>Orphanet J Rare Dis. 2018 <\/strong>Oct 29;13(1):190. doi: 10.1186\/s13023-018-0920-5. PMID: 30373615.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29802948\/\" target=\"_blank\">The P2X4 purinergic receptor regulates hepatic myofibroblast activation during liver fibrogenesis.<\/a><\/strong> Le Guilcher C, Garcin I, Dellis O, Cauchois F, Tebbi A, Doignon I, Guettier C, Julien B, Tordjmann T. <strong>J Hepatol. 2018 <\/strong>Sep;69(3):644-653. doi: 10.1016\/j.jhep.2018.05.020. PMID: 29802948.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29704327\/\" target=\"_blank\">Morphological characterization of chronic antibody-mediated rejection in ABO-identical or ABO-compatible pediatric liver graft recipients.<\/a><\/strong> Dao M, Hab\u00e8s D, Taupin JL, Mussini C, Redon MJ, Suberbielle C, Jacquemin E, Gonzales E, Guettier C. <strong>Liver Transpl. 2018<\/strong> Jul;24(7):897-907. doi: 10.1002\/lt.25187. PMID: 29704327.<\/li><\/ul>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\"><strong>2017<\/strong><\/h5>\n\n\n\n<ul class=\"has-medium-font-size\"><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29200391\/\" target=\"_blank\">[Gal-9 promotes viral persistence of&nbsp;hepatitis virus in the liver].<\/a><\/strong> Zahaf A, Badia A, Morel J, Dellis O. La galectine-9 favorise la persistance du virus de l\u2019h\u00e9patite C dans le foie. <strong>Med Sci (Paris). 2017 <\/strong>Nov;33(11):947-949. French. doi: 10.1051\/medsci\/20173311010. PMID: 29200391.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28990561\/\" target=\"_blank\">[Cholestasis-induced liver injury: the role of S1PR2].<\/a><\/strong> Dissous L, Cesard E, Dance A, Tordjmann T. Les l\u00e9sions h\u00e9patiques induites par la cholestase&nbsp;: le r\u00f4le de S1PR2. <strong>Med Sci (Paris). 2017 <\/strong>Jun-Jul;33(6-7):606-609. French. doi: 10.1051\/medsci\/20173306016. PMID: 28990561.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28792652\/\" target=\"_blank\">Mutations in the novel gene FOPV are associated with familial autosomal dominant and non-familial obliterative portal venopathy.<\/a><\/strong> Besmond C, Valla D, Hubert L, Poirier K, Grosse B, Guettier C, Bernard O, Gonzales E, Jacquemin E. <strong>Liver Int. 2018 <\/strong>Feb;38(2):358-364. doi: 10.1111\/liv.13547. PMID: 28792652.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28727657\/\" target=\"_blank\">Cholic Acid to Treat HSD3B7 and AKR1D1 Deficiencies.<\/a><\/strong> Jacquemin E, Gonzales E. <strong>J Pediatr Gastroenterol Nutr. 2017 <\/strong>Dec;65(6):e134. doi: 10.1097\/MPG.0000000000001693. PMID: 28727657.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28302491\/\" target=\"_blank\">Bile acids and their receptors during liver regeneration: \u00ab\u00a0Dangerous protectors\u00a0\u00bb.<\/a><\/strong> Merlen G, Ursic-Bedoya J, Jourdainne V, Kahale N, Glenisson M, Doignon I, Rainteau D, Tordjmann T. <strong>Mol Aspects Med. 2017 <\/strong>Aug;56:25-33. doi: 10.1016\/j.mam.2017.03.002. PMID: 28302491.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28267072\/\" target=\"_blank\">Attempt to Determine the Prevalence of Two Inborn Errors of Primary Bile Acid Synthesis: Results of a European Survey.<\/a><\/strong> Jahnel J, Z\u00f6hrer E, Fischler B, D&rsquo;Antiga L, Debray D, Dezsofi A, Haas D, Hadzic N, Jacquemin E, Lamireau T, Maggiore G, McKiernan PJ, Calvo PL, Verkade HJ, Hierro L, McLin V, Baumann U, Gonzales E. <strong>J Pediatr Gastroenterol Nutr. 2017<\/strong> Jun;64(6):864-868. doi: 10.1097\/MPG.0000000000001546. PMID: 28267072.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28245962\/\" target=\"_blank\">Targeted pharmacotherapies for defective ABC transporters.<\/a><\/strong> Vauthier V, Housset C, Falgui\u00e8res T. <strong>Biochem Pharmacol. 2017 <\/strong>Jul 15;136:1-11. doi: 10.1016\/j.bcp.2017.02.020. PMID: 28245962.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27557426\/\" target=\"_blank\">Sertraline as an Additional Treatment for Cholestatic Pruritus in Children.<\/a><\/strong> Th\u00e9baut A, Habes D, Gottrand F, Rivet C, Cohen J, Debray D, Jacquemin E, Gonzales E. <strong>J Pediatr Gastroenterol Nutr. 2017 <\/strong>Mar;64(3):431-435. doi: 10.1097\/MPG.0000000000001385. PMID: 27557426.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27532546\/\" target=\"_blank\">MYO5B mutations cause cholestasis with normal serum gamma-glutamyl transferase activity in children without microvillous inclusion disease.<\/a><\/strong> Gonzales E, Taylor SA, Davit-Spraul A, Th\u00e9baut A, Thomassin N, Guettier C, Whitington PF, Jacquemin E. <strong>Hepatology. 2017 <\/strong>Jan;65(1):164-173. doi: 10.1002\/hep.28779. PMID: 27532546.<\/li><\/ul>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\"><strong>2016<\/strong><\/h5>\n\n\n\n<ul class=\"has-medium-font-size\"><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27429423\/\" target=\"_blank\">Oral Tocofersolan Corrects or Prevents Vitamin E Deficiency in Children With Chronic Cholestasis.<\/a><\/strong> Th\u00e9baut A, Nemeth A, Le Mouha\u00ebr J, Scheenstra R, Baumann U, Koot B, Gottrand F, Houwen R, Monard L, de Micheaux SL, Habes D, Jacquemin E. <strong>J Pediatr Gastroenterol Nutr. 2016 <\/strong>Dec;63(6):610-615. doi: 10.1097\/MPG.0000000000001331. PMID: 27429423.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27406767\/\" target=\"_blank\">[Cholangiocyte proliferation induced by bile acids: impact of TGR5].<\/a><\/strong> Barichon C, Correia C, Tordjmann T. La prolif\u00e9ration des cholangiocytes induite par les acides biliaires : place du r\u00e9cepteur TGR5. <strong>Med Sci (Paris). 2016 <\/strong>Jun-Jul;32(6-7):585-7. French. doi: 10.1051\/medsci\/20163206020. PMID: 27406767.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27301647\/\" target=\"_blank\">The P2X4 purinergic receptor impacts liver regeneration after partial hepatectomy in mice through the regulation of biliary homeostasis.<\/a><\/strong> Besnard A, Gautherot J, Julien B, Tebbi A, Garcin I, Doignon I, P\u00e9an N, Gonzales E, Cassio D, Grosse B, Liu B, Safya H, Cauchois F, Humbert L, Rainteau D, Tordjmann T. <strong>Hepatology. 2016 <\/strong>Sep;64(3):941-53. doi: 10.1002\/hep.28675. PMID: 27301647.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26829045\/\" target=\"_blank\">Cholestasis Reveals Severe Cortisol Deficiency in Neonatal Pituitary Stalk Interruption Syndrome.<\/a><\/strong> Mauvais FX, Gonzales E, Davit-Spraul A, Jacquemin E, Brauner R. <strong>PLoS One. 2016 <\/strong>Feb 1;11(2):e0147750. doi: 10.1371\/journal.pone.0147750. PMID: 26829045.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26628447\/\" target=\"_blank\">Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders.<\/a><\/strong> Kremer AE, Gonzales E, Schaap FG, Oude Elferink RP, Jacquemin E, Beuers U. <strong>J Pediatr Gastroenterol Nutr. 2016 <\/strong>Apr;62(4):530-5. doi: 10.1097\/MPG.0000000000001044. PMID: 26628447.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26474921\/\" target=\"_blank\">A functional classification of ABCB4 variations causing progressive familial intrahepatic cholestasis type 3.<\/a><\/strong> Delaunay JL, Durand-Schneider AM, Dossier C, Falgui\u00e8res T, Gautherot J, Davit-Spraul A, A\u00eft-Slimane T, Housset C, Jacquemin E, Maurice M. <strong>Hepatology. 2016 <\/strong>May;63(5):1620-31. doi: 10.1002\/hep.28300. PMID: 26474921.<\/li><\/ul>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\"><strong>2015<\/strong><\/h5>\n\n\n\n<ul class=\"has-medium-font-size\"><li><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26045264\/\" target=\"_blank\"><strong>The Bile Acid Receptor TGR5 and Liver Regeneration.<\/strong><\/a> Jourdainne V, P\u00e9an N, Doignon I, Humbert L, Rainteau D, Tordjmann T. <strong>Dig Dis. 2015<\/strong>;33(3):319-26. doi: 10.1159\/000371668. PMID: 26045264.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25963393\/\" target=\"_blank\">Potentiation of the store-operated calcium entry (SOCE) induces phytohemagglutinin-activated Jurkat T cell apoptosis.<\/a><\/strong> Djillani A, Doignon I, Luyten T, Lamkhioued B, Gangloff SC, Parys JB, N\u00fc\u00dfe O, Chomienne C, Dellis O. <strong>Cell Calcium. 2015 <\/strong>Aug;58(2):171-85. doi: 10.1016\/j.ceca.2015.04.005. PMID: 25963393.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25716872\/\" target=\"_blank\">Targeted pharmacotherapy in progressive familial intrahepatic cholestasis type 2: Evidence for improvement of cholestasis with 4-phenylbutyrate.<\/a><\/strong> Gonzales E, Grosse B, Schuller B, Davit-Spraul A, Conti F, Guettier C, Cassio D, Jacquemin E. <strong>Hepatology. 2015 <\/strong>Aug;62(2):558-66. doi: 10.1002\/hep.27767. PMID: 25716872.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25654989\/\" target=\"_blank\">Bile acids and FGF receptors: orchestrators of optimal liver regeneration.<\/a><\/strong> Gilgenkrantz H, Tordjmann T. <strong>Gut. 2015 <\/strong>Sep;64(9):1351-2. doi: 10.1136\/gutjnl-2014-308746. PMID: 25654989.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25383612\/\" target=\"_blank\">Paramecium swimming and ciliary beating patterns: a study on four RNA interference mutations.<\/a><\/strong> Funfak A, Fisch C, Abdel Motaal HT, Diener J, Combettes L, Baroud CN, Dupuis-Williams P. <strong>Integr Biol (Camb). 2015 <\/strong>Jan;7(1):90-100. doi: 10.1039\/c4ib00181h. PMID: 25383612.<\/li><\/ul>\n\n\n\n<h5 class=\"alignwide has-text-color has-large-font-size\" style=\"color:#63003c\"><strong>2014<\/strong><\/h5>\n\n\n\n<ul class=\"has-medium-font-size\"><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25085279\/\" target=\"_blank\">Liver transcript analysis reveals aberrant splicing due to silent and intronic variations in the ABCB11 gene.<\/a><\/strong> Davit-Spraul A, Oliveira C, Gonzales E, Gaignard P, Th\u00e9rond P, Jacquemin E. <strong>Mol Genet Metab. 2014 <\/strong>Nov;113(3):225-9. doi: 10.1016\/j.ymgme.2014.07.006. PMID: 25085279.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24953525\/\" target=\"_blank\">ABCB4: Insights from pathobiology into therapy.<\/a><\/strong> Falgui\u00e8res T, A\u00eft-Slimane T, Housset C, Maurice M. <strong>Clin Res Hepatol Gastroenterol. 2014 <\/strong>Oct;38(5):557-63. doi: 10.1016\/j.clinre.2014.03.001. PMID: 24953525.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24723470\/\" target=\"_blank\">Phosphorylation of ABCB4 impacts its function: insights from disease-causing mutations.<\/a><\/strong> Gautherot J, Delautier D, Maubert MA, A\u00eft-Slimane T, Bolbach G, Delaunay JL, Durand-Schneider AM, Firrincieli D, Barbu V, Chignard N, Housset C, Maurice M, Falgui\u00e8res T. <strong>Hepatology. 2014 <\/strong>Aug;60(2):610-21. doi: 10.1002\/hep.27170. PMID: 24723470.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24657813\/\" target=\"_blank\">Characterization of novel store-operated calcium entry effectors.<\/a><\/strong> Djillani A, N\u00fc\u00dfe O, Dellis O. <strong>Biochim Biophys Acta. <\/strong>2014 Oct;1843(10):2341-7. doi: 10.1016\/j.bbamcr.2014.03.012. PMID: 24657813.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24214725\/\" target=\"_blank\">Secondary Mitochondrial Respiratory Chain Defect Can Delay Accurate PFIC2 Diagnosis.<\/a><\/strong> Davit-Spraul A, Beinat M, Debray D, R\u00f6tig A, Slama A, Jacquemin E. <strong>JIMD Rep. 2014<\/strong>;14:17-21. doi: 10.1007\/8904_2013_278. Epub 2013 Nov 9. PMID: 24214725.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24002166\/\" target=\"_blank\">Clinical utility gene card for: progressive familial intrahepatic cholestasis type 3.<\/a><\/strong> Gonzales E, Spraul A, Jacquemin E. <strong>Eur J Hum Genet. 2014 <\/strong>Apr;22(4). doi: 10.1038\/ejhg.2013.188. PMID: 24002166.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23982689\/\" target=\"_blank\">Clinical utility gene card for: progressive familial intrahepatic cholestasis type 2.<\/a><\/strong> Gonzales E, Spraul A, Jacquemin E. <strong>Eur J Hum Genet. 2014 <\/strong>Apr;22(4). doi: 10.1038\/ejhg.2013.187. PMID: 23982689.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23982690\/\" target=\"_blank\">Clinical utility gene card for: progressive familial intrahepatic cholestasis type 1.<\/a><\/strong> Gonzales E, Spraul A, Jacquemin E. <strong>Eur J Hum Genet. 2014 <\/strong>Apr;22(4). doi: 10.1038\/ejhg.2013.186. PMID: 23982690.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23916556\/\" target=\"_blank\">Gut microbiota and bile acids: an old story revisited (again).<\/a><\/strong> P\u00e9an N, Doignon I, Tordjmann T. <strong>Clin Res Hepatol Gastroenterol. 2014 <\/strong>Apr;38(2):129-31. doi: 10.1016\/j.clinre.2013.06.006. PMID: 23916556.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23686672\/\" target=\"_blank\">The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice.<\/a><\/strong> P\u00e9an N, Doignon I, Garcin I, Besnard A, Julien B, Liu B, Branchereau S, Spraul A, Guettier C, Humbert L, Schoonjans K, Rainteau D, Tordjmann T. <strong>Hepatology. 2013 <\/strong>Oct;58(4):1451-60. doi: 10.1002\/hep.26463. PMID: 23686672.<\/li><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23636179\/\" target=\"_blank\">Arthrogryposis, renal dysfunction, and cholestasis syndrome caused by VIPAR mutation.<\/a><\/strong> Ackermann O, Gonzales E, Keller M, Guettier C, Gissen P, Jacquemin E. <strong>J Pediatr Gastroenterol Nutr. 2014 <\/strong>Mar;58(3):e29-32. doi: 10.1097\/MPG.0b013e318298108f. PMID: 23636179.<\/li><\/ul>\n<\/div>\n\n\n\n<div class=\"wp-container-44 wp-block-group alignwide\">\n<h3 class=\"alignwide has-text-align-center has-background-color has-text-color has-background\" style=\"background-color:#63003c\"><strong>Collaborations and partnerships<\/strong><\/h3>\n\n\n\n<h2 class=\"alignwide has-text-align-center has-foreground-color has-text-color\"><strong>Under construction...<\/strong><\/h2>\n\n\n\n<p><\/p>\n<\/div>\n\n\n\n<div class=\"wp-container-55 wp-block-group alignwide\">\n<h3 class=\"alignwide has-text-align-center has-background-color has-text-color has-background\" style=\"background-color:#63003c\"><strong>Our funders<\/strong><\/h3>\n\n\n\n<div class=\"wp-container-49 is-layout-flex wp-block-columns alignwide are-vertically-aligned-center\">\n<div class=\"wp-container-45 wp-block-column is-vertically-aligned-center\" style=\"--col-width:25%;flex-basis:25%\">\n<figure class=\"wp-block-image aligncenter size-large is-resized is-style-default\"><a 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Thierry Tordjmann Hom\u00e9ostasie biliaire et r\u00e9paration du foie Activit\u00e9s de Recherche 1. Hom\u00e9ostasie biliaire et r\u00e9paration h\u00e9patique Responsable : Dr Thierry Tordjmann M\u00eame si la capacit\u00e9 de r\u00e9g\u00e9n\u00e9ration du foie est importante, la r\u00e9paration tissulaire lors de l\u00e9sions chroniques (d\u2019\u00e9tiologies biliaires ou non biliaires) peut entra\u00eener une fibrose h\u00e9patique. Il est important [&hellip;]<\/p>","protected":false},"author":8,"featured_media":0,"parent":566,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"wp-custom-template-mon-modele","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Equipe 4 - Thierry Tordjmann - UMR-S 1193 HEPAREG<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Equipe 4 - Thierry Tordjmann - UMR-S 1193 HEPAREG\" \/>\n<meta property=\"og:description\" content=\"Equipe 4 &#8211; Thierry Tordjmann Hom\u00e9ostasie biliaire et r\u00e9paration du foie Activit\u00e9s de Recherche 1. Hom\u00e9ostasie biliaire et r\u00e9paration h\u00e9patique Responsable : Dr Thierry Tordjmann M\u00eame si la capacit\u00e9 de r\u00e9g\u00e9n\u00e9ration du foie est importante, la r\u00e9paration tissulaire lors de l\u00e9sions chroniques (d\u2019\u00e9tiologies biliaires ou non biliaires) peut entra\u00eener une fibrose h\u00e9patique. 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