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Equipe 1 – Didier Samuel
Innovations thérapeutiques dans les malades du foie et la transplantation
Recherche translationnelle
Activités de recherche
Projet 1
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed in nibh risus. Nulla pharetra fermentum feugiat. Duis non mauris elit. Sed scelerisque libero nunc, vel pretium enim laoreet sit amet. Cras gravida justo vel sem imperdiet pharetra. Donec at tortor eu tortor blandit vehicula. Mauris non massa sed dui volutpat fermentum vel non ex.
Projet 2
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed in nibh risus. Nulla pharetra fermentum feugiat. Duis non mauris elit. Sed scelerisque libero nunc, vel pretium enim laoreet sit amet. Cras gravida justo vel sem imperdiet pharetra. Donec at tortor eu tortor blandit vehicula. Mauris non massa sed dui volutpat fermentum vel non ex.
Projet 3
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed in nibh risus. Nulla pharetra fermentum feugiat. Duis non mauris elit. Sed scelerisque libero nunc, vel pretium enim laoreet sit amet. Cras gravida justo vel sem imperdiet pharetra. Donec at tortor eu tortor blandit vehicula. Mauris non massa sed dui volutpat fermentum vel non ex.
Projet 4
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed in nibh risus. Nulla pharetra fermentum feugiat. Duis non mauris elit. Sed scelerisque libero nunc, vel pretium enim laoreet sit amet. Cras gravida justo vel sem imperdiet pharetra. Donec at tortor eu tortor blandit vehicula. Mauris non massa sed dui volutpat fermentum vel non ex.
Membres de l’équipe
Michel DUPONT
PU-PH
AP-HP / UP-Saclay
01-69-15-XX-XX
michel.dupont@université.paris-saclay.fr
Joceline ANDRE
MCU
Université-Paris-Saclay
01-69-15-XX-XX
joceline.andre@université.paris-saclay.fr
Thomas PIERRE
Chargé de Recherche
Inserm
01-69-15-XX-XX
thomas.pierre@université.paris-saclay.fr
Stéphanie ROGER
Ingénieur d’Etudes
Inserm
01-69-15-XX-XX
stephanie.roger@université.paris-saclay.fr
Aurore LOREAL
Technicienne
Université-Paris-Saclay
01-69-15-XX-XX
aurore.loreal@université.paris-saclay.fr
Michel DUPONT
PU-PH
AP-HP / UP-Saclay
01-69-15-XX-XX
michel.dupont@université.paris-saclay.fr
Joceline ANDRE
MCU
Université-Paris-Saclay
01-69-15-XX-XX
joceline.andre@université.paris-saclay.fr
Thomas PIERRE
Chargé de Recherche
Inserm
01-69-15-XX-XX
thomas.pierre@université.paris-saclay.fr
Stéphanie ROGER
Ingénieur d’Etudes
Inserm
01-69-15-XX-XX
stephanie.roger@université.paris-saclay.fr
Aurore LOREAL
Technicienne
Université-Paris-Saclay
01-69-15-XX-XX
aurore.loreal@université.paris-saclay.fr
Michel DUPONT
PU-PH
AP-HP / UP-Saclay
01-69-15-XX-XX
michel.dupont@université.paris-saclay.fr
Joceline ANDRE
MCU
Université-Paris-Saclay
01-69-15-XX-XX
joceline.andre@université.paris-saclay.fr
Thomas PIERRE
Chargé de Recherche
Inserm
01-69-15-XX-XX
thomas.pierre@université.paris-saclay.fr
Stéphanie ROGER
Ingénieur d’Etudes
Inserm
01-69-15-XX-XX
stephanie.roger@université.paris-saclay.fr
Aurore LOREAL
Technicienne
Université-Paris-Saclay
01-69-15-XX-XX
aurore.loreal@université.paris-saclay.fr
Publications
- ABC Transporters in Human Diseases: Future Directions and Therapeutic Perspectives.
Falguières T. Int J Mol Sci. 2022 Apr 12;23(8):4250. doi: 10.3390/ijms23084250. PMID: 35457067; PMCID: PMC9028344. - MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression. Bruneau A, Delaunay JL, Durand-Schneider AM, Vauthier V, Ben Saad A, Aoudjehane L, El Mourabit H, Morichon R, Falguières T, Gautheron J, Housset C, Aït-Slimane T. Cells. 2022 Feb 10;11(4):617. doi: 10.3390/cells11040617. PMID: 35203270; PMCID: PMC8870398.
- In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy. Mareux E, Lapalus M, Ben-Saad A, Callebaut I, Falguières T, Gonzales E, Jacquemin E. Orphanet J Rare Dis. 2021 Nov 18;16(1):484. doi: 10.1186/s13023-021-02125-4. PMID: 34794484; PMCID: PMC8600881.
- RAB10 Interacts with ABCB4 and Regulates Its Intracellular Traffic. Ben Saad A, Vauthier V, Lapalus M, Mareux E, Bennana E, Durand-Schneider AM, Bruneau A, Delaunay JL, Gonzales E, Housset C, Aït-Slimane T, Guillonneau F, Jacquemin E, Falguières T. Int J Mol Sci. 2021 Jun 30;22(13):7087. doi: 10.3390/ijms22137087. PMID: 34209301; PMCID: PMC8268348.
- Molecular Regulation of Canalicular ABC Transporters. Ben Saad A, Bruneau A, Mareux E, Lapalus M, Delaunay JL, Gonzales E, Jacquemin E, Aït-Slimane T, Falguières T. Int J Mol Sci. 2021 Feb 20;22(4):2113. doi: 10.3390/ijms22042113. PMID: 33672718; PMCID: PMC7924332.
- Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants. Ben Saad A, Vauthier V, Tóth Á, Janaszkiewicz A, Durand-Schneider AM, Bruneau A, Delaunay JL, Lapalus M, Mareux E, Garcin I, Gonzales E, Housset C, Aït-Slimane T, Jacquemin E, Di Meo F, Falguières T. Liver Int. 2021 Jun;41(6):1344-1357. doi: 10.1111/liv.14839. Epub 2021 Mar 25. PMID: 33650203.
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