FR 
EN Equipe 2 – François Le Naour
Bioconstruction d’organoïdes hépatiques
Modélisation et signature des maladies hépatiques
Activités de recherche
en construction
Les projets
en construction
Projet 1
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Projet 2
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed in nibh risus. Nulla pharetra fermentum feugiat. Duis non mauris elit. Sed scelerisque libero nunc, vel pretium enim laoreet sit amet. Cras gravida justo vel sem imperdiet pharetra. Donec at tortor eu tortor blandit vehicula. Mauris non massa sed dui volutpat fermentum vel non ex.
Projet 3
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed in nibh risus. Nulla pharetra fermentum feugiat. Duis non mauris elit. Sed scelerisque libero nunc, vel pretium enim laoreet sit amet. Cras gravida justo vel sem imperdiet pharetra. Donec at tortor eu tortor blandit vehicula. Mauris non massa sed dui volutpat fermentum vel non ex.
Projet 4
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed in nibh risus. Nulla pharetra fermentum feugiat. Duis non mauris elit. Sed scelerisque libero nunc, vel pretium enim laoreet sit amet. Cras gravida justo vel sem imperdiet pharetra. Donec at tortor eu tortor blandit vehicula. Mauris non massa sed dui volutpat fermentum vel non ex.
Membres de l’équipe
en construction
Cellules souches et foie
Anne DUBART-KUPPERSCHMITT
DR2 INSERM
01-45-59-51-38
anne.dubart@inserm.fr
Antonietta MESSINA
Post-Doc INSERM
01-45-59-52-17
antonietta.messina@inserm.fr
Eléanor LUCE
Ingénieur Recherche INSERM
01-49-59-52-23
eleanor.luce@inserm.fr
Nassima BENZOUBIR
Technicienne Université Paris-Saclay
01-45-59-52-17
nassima.benzoubir@inserm.fr
Meriem SAIDANI
Ingénieur Etude INSERM
01-49-59-52-23
meriem.saidani@inserm.fr
Jean-Charles DUCLOS-VALLEE
PU-PH
Université Paris-Saclay
01-45-59-30-42
jean-charles.duclos-vallee@aphp.fr
Joceline ANDRE
MCU
Université-Paris-Saclay
01-69-15-XX-XX
joceline.andre@université.paris-saclay.fr
Thomas PIERRE
Chargé de Recherche
Inserm
01-69-15-XX-XX
thomas.pierre@université.paris-saclay.fr
Stéphanie ROGER
Ingénieur d’Etudes
Inserm
01-69-15-XX-XX
stephanie.roger@université.paris-saclay.fr
Aurore LOREAL
Technicienne
Université-Paris-Saclay
01-69-15-XX-XX
aurore.loreal@université.paris-saclay.fr
Michel DUPONT
PU-PH
AP-HP / UP-Saclay
01-69-15-XX-XX
michel.dupont@université.paris-saclay.fr
Joceline ANDRE
MCU
Université-Paris-Saclay
01-69-15-XX-XX
joceline.andre@université.paris-saclay.fr
Thomas PIERRE
Chargé de Recherche
Inserm
01-69-15-XX-XX
thomas.pierre@université.paris-saclay.fr
Stéphanie ROGER
Ingénieur d’Etudes
Inserm
01-69-15-XX-XX
stephanie.roger@université.paris-saclay.fr
Aurore LOREAL
Technicienne
Université-Paris-Saclay
01-69-15-XX-XX
aurore.loreal@université.paris-saclay.fr
Publications
2022 : cellules souches et foie
- Evidence of Adult Features and Functions of Hepatocytes Differentiated from Human Induced Pluripotent Stem Cells and Self-Organized as Organoids. Messina A, Luce E, Benzoubir N, Pasqua M, Pereira U, Humbert L, Eguether T, Rainteau D, Duclos-Vallée JC, Legallais C, Dubart-Kupperschmitt A. Cells. 2022 Feb 4;11(3):537. doi: 10.3390/cells11030537. PMID: 35159346
- In vitro recovery of FIX clotting activity as a marker of highly functional hepatocytes in a hemophilia B iPSC model. Luce E, Steichen C, Allouche M, Messina A, Heslan JM, Lambert T, Weber A, Nguyen TH, Christophe O, Dubart-Kupperschmitt A. Hepatology. 2022 Apr;75(4):866-880. doi: 10.1002/hep.32211. Epub 2021 Dec 12. PMID: 34687060
2021 : cellules souches et foie
- A versatile microfluidic tool for the 3D culture of HepaRG cells seeded at various stages of differentiation. Boul M, Benzoubir N, Messina A, Ghasemi R, Mosbah IB, Duclos-Vallée JC, Dubart-Kupperschmitt A, Le Pioufle B. Sci Rep. 2021 Jul 7;11(1):14075. doi: 10.1038/s41598-021-92011-7. PMID: 34234159
- [Hepatic organoids: What are the challenges?]. Luce E, Messina A, Caillaud A, Si-Tayeb K, Cariou B, Bur E, Dubart-Kupperschmitt A, Duclos-Vallée JC. Med Sci (Paris). 2021 Oct;37(10):902-909. doi: 10.1051/medsci/2021119. Epub 2021 Oct 14. PMID: 34647879
- Advanced Techniques and Awaited Clinical Applications for Human Pluripotent Stem Cell Differentiation into Hepatocytes. Luce E, Messina A, Duclos-Vallée JC, Dubart-Kupperschmitt A. Hepatology. 2021 Aug;74(2):1101-1116. doi: 10.1002/hep.31705. Epub 2021 Aug 22. PMID: 33420753
2020 : cellules souches et foie
- Pluripotent-Stem-Cell-Derived Hepatic Cells: Hepatocytes and Organoids for Liver Therapy and Regeneration. Messina A, Luce E, Hussein M, Dubart-Kupperschmitt A. Cells. 2020 Feb 12;9(2):420. doi: 10.3390/cells9020420. PMID: 32059501
- HepaRG Self-Assembled Spheroids in Alginate Beads Meet the Clinical Needs for Bioartificial Liver. Pasqua M, Pereira U, Messina A, de Lartigue C, Vigneron P, Dubart-Kupperschmitt A, Legallais C. Tissue Eng Part A. 2020 Jun;26(11-12):613-622. doi: 10.1089/ten.TEA.2019.0262. Epub 2020 Feb 12. PMID: 31914890
- Pluripotent stem cell-derived cholangiocytes and cholangiocyte organoids. Luce E, Dubart-Kupperschmitt A. Methods Cell Biol. 2020;159:69-93. doi: 10.1016/bs.mcb.2020.03.011. Epub 2020 May 19. PMID: 32586450
- Liver Regeneration and Recanalization Time Course following Repeated Reversible Portal Vein Embolization in Swine. Gaillard M, Hornez E, Lecuelle B, Lilin T, Dubart-Kupperschmitt A, Dagher I, Tranchart H. Eur Surg Res. 2020;61(2-3):62-71. doi: 10.1159/000509713. Epub 2020 Oct 13. PMID: 33049754
2019 : cellules souches et foie
- Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection. Caron J, Pène V, Tolosa L, Villaret M, Luce E, Fourrier A, Heslan JM, Saheb S, Bruckert E, Gómez-Lechón MJ, Nguyen TH, Rosenberg AR, Weber A, Dubart-Kupperschmitt A. Stem Cell Res Ther. 2019 Jul 29;10(1):221. doi: 10.1186/s13287-019-1342-6. PMID: 31358055
- Genomic integrity of human induced pluripotent stem cells: Reprogramming, differentiation and applications. Steichen C, Hannoun Z, Luce E, Hauet T, Dubart-Kupperschmitt A. World J Stem Cells. 2019 Oct 26;11(10):729-747. doi: 10.4252/wjsc.v11.i10.729. PMID: 31692979
- Improving Hepatocyte Engraftment Following Hepatocyte Transplantation Using Repeated Reversible Portal Vein Embolization in Rats. Gaillard M, Tranchart H, Lainas P, Trassard O, Remy S, Dubart-Kupperschmitt A, Dagher I. Liver Transpl. 2019 Jan;25(1):98-110. doi: 10.1002/lt.25364. PMID: 30358068
2017 : cellules souches et foie
- Advanced cell-based modeling of the royal disease: characterization of the mutated F9 mRNA. Martorell L, Luce E, Vazquez JL, Richaud-Patin Y, Jimenez-Delgado S, Corrales I, Borras N, Casacuberta-Serra S, Weber A, Parra R, Altisent C, Follenzi A, Dubart-Kupperschmitt A, Raya A, Vidal F, Barquinero J. J Thromb Haemost. 2017 Nov;15(11):2188-2197. doi: 10.1111/jth.13808. Epub 2017 Sep 25. PMID: 28834196
2016 : cellules souches et foie
- The potential of induced pluripotent stem cell derived hepatocytes. Hannoun Z, Steichen C, Dianat N, Weber A, Dubart-Kupperschmitt A. J Hepatol. 2016 Jul;65(1):182-199. doi: 10.1016/j.jhep.2016.02.025. Epub 2016 Feb 22. PMID: 26916529
- Hepatocytic Differentiation Potential of Human Fetal Liver Mesenchymal Stem Cells: In Vitro and In Vivo Evaluation. El-Kehdy H, Pourcher G, Zhang W, Hamidouche Z, Goulinet-Mainot S, Sokal E, Charbord P, Najimi M, Dubart-Kupperschmitt A. Stem Cells Int. 2016;2016:6323486. doi: 10.1155/2016/6323486. Epub 2016 Jan 13. PMID: 27057173
- [Human pluripotent stem cells and liver disorders]. Dianat N, Weber A, Dubart-Kupperschmitt A. Biol Aujourdhui. 2016;210(1):19-26. doi: 10.1051/jbio/2016006. Epub 2016 Jun 10. PMID: 27286577
- Rapid and reliable diagnosis of Wilson disease using X-ray fluorescence. Kaščáková S, Kewish CM, Rouzière S, Schmitt F, Sobesky R, Poupon J, Sandt C, Francou B, Somogyi A, Samuel D, Jacquemin E, Dubart-Kupperschmitt A, Nguyen TH, Bazin D, Duclos-Vallée JC, Guettier C, Le Naour F. J Pathol Clin Res. 2016 Jun 6;2(3):175-86. doi: 10.1002/cjp2.48. eCollection 2016 Jul. PMID: 27499926
- Volumetric Portal Embolization: A New Concept to Improve Liver Regeneration and Hepatocyte Engraftment. Pourcher G, El-Kehdy H, Kanso F, Groyer-Picard MT, Gaillard M, Trassard O, Blazsek I, Agostini H, Dubart-Kupperschmitt A, Dagher I. Transplantation. 2016 Feb;100(2):344-54. doi: 10.1097/TP.0000000000001024. PMID: 26757049
- Liver regeneration following repeated reversible portal vein embolization in an experimental model. Tranchart H, Koffi GM, Gaillard M, Lainas P, Poüs C, Gonin P, Nguyen TH, Dubart-Kupperschmitt A, Dagher I. Br J Surg. 2016 Aug;103(9):1209-19. doi: 10.1002/bjs.10153. Epub 2016 Jun 3. PMID: 27256140
2015 : cellules souches et foie
- Transplantation of hESC-derived hepatocytes protects mice from liver injury. Tolosa L, Caron J, Hannoun Z, Antoni M, López S, Burks D, Castell JV, Weber A, Gomez-Lechon MJ, Dubart-Kupperschmitt A. Stem Cell Res Ther. 2015 Dec 12;6:246. doi: 10.1186/s13287-015-0227-6. PMID: 26652177
- An atypical human induced pluripotent stem cell line with a complex, stable, and balanced genomic rearrangement including a large de novo 1q uniparental disomy. Steichen C, Maluenda J, Tosca L, Luce E, Pineau D, Dianat N, Hannoun Z, Tachdjian G, Melki J, Dubart-Kupperschmitt A. Stem Cells Transl Med. 2015 Mar;4(3):224-9. doi: 10.5966/sctm.2014-0186. Epub 2015 Feb 3. PMID: 25650439
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